M FREAKY
Super Moderator
Glutamine!!!
Scientifically speaking, glutamine is one of the 20 amino acids formed by the human body. Glutamine is considered a non-essential amino acid because it can be derived from glutamic acid, another member of the amino acid family. Both glutamine and glutamic acid can be found in protein-rich foods such as beans, red meat, nuts and fish. The body uses glutamine to improve mental function, control blood sugar levels and maintain muscle mass, among other applications.
As a supplement, glutamine is seen as both a 'brain food' and a muscle mass enhancer for body builders. Physicians have been known to use glutamine for the treatment of alcoholism, mild depression and muscle-wasting conditions such as Huntington's disease. Glutamine is actually the most common free-form amino acid found floating in muscle tissues. During times of stress, the body may draw glutamine away from the muscles in order to bolster the immune system or prevent blood sugar reactions. This is why many bodybuilders and other proponents of supplements often add daily doses of glutamine to maintain good muscle health.
The average diet provides anywhere from 5 to 8 grams of glutamine a day. It would not be unusual for bodybuilders in training to boost this level to 10 grams or more with glutamine supplements. Others who need to control blood sugar levels may also benefit from additional glutamine. Some non-scientific studies suggest that glutamine may also help improve mental function, because the body naturally uses glutamine to transport nitrogen to the brain and nervous system.
The human body does require a daily intake of glutamine, so the use of supplements is not generally seen as harmful or unnecessary. Higher doses of glutamine may cause unpleasant side effects such as diarrhea, but most healthy bodies can safely assimilate the excess amino acid. Supplemental glutamine simply remains suspended in muscle tissue unless drawn away for other uses by the body. Some people also discover that elevated glutamine levels reduce their desire for sweets or between-meal snacks.
Now Remember the difference between glutamine peptides and regular L-glutamine Peptides are different from free form amino acids because they are basically 2 or more amino acids (building blocks of proteins) which are chemically linked to each other. Your body naturally takes whole proteins (made of long chains of aminos) and breaks them down through a natural hydrolyzation process to produce smaller and smaller peptides so they can be absorbed. Free form aminos like regular L-glutamine are just the single amino acid.
The glutamine dipeptides are typically L-glutamine bonded with either L-Alanine or L-Glycine. So you can look at this two ways as either a positive or a negative.
1. Peptides have a faster absorption rate in peptide form. Or
2. You are buying X number of grams of glutamine and in reality only getting 50% of that as actual glutamine.
Facts:
The maximum size amino chain your body can absorb is a 3 am ino peptide.
Nearly 75% of ingested protein is absorbed across the intestine in the form of peptides.
Why?
It is more efficient or “faster” for your body to absorb 3 am inos at a time vs. just one at a time. This is why companies say they are up to 150% more efficient than free form. Get it?
A problem with Peptides in my opinion:
Since amino acid peptides are more absorbed more quickly they may produce a greater insulin reaction. Depending on the timing this can be good or bad. Post workout is OK. However, most of the rest of the time you want to stabilize insulin reactions to avoid potential blood sugar fluctuations and subsequent possible body fat accumulation.
Research:
Other than speed of absorption, studies have shown that glutamine and glutamine dipeptides exert similar positive metabolic effects.
In one recent, double-blind, randomized, controlled study, duration of hospital stay was significantly reduced in patients who had undergone major abdominal surgery and who had received glutamine dipeptides via TPN over a five-day period. Mean cumulative nitrogen balance was significantly better in these patients, as was immune function.
The anticatabolic/anabolic action of both glutamine and glutamine dipeptides can be explained by their effect in sparing skeletal muscle L-glutamine stores. Most of the L-glutamine in the body is synthesized in skeletal muscle, where it is also stored. Under conditions of metabolic stress, skeletal muscle can be depleted of its L-glutamine, which is used for metabolic activities of other tissue/cells, such as enterocytes and lymphocytes (feeding the immune system to protect your main antioxidant glutathione).
The gastrointestinal mucosal-protective effect of the glutamine dipeptides can be explained in a few ways. L-glutamine is the preferred respiratory fuel for enterocytes and colonocytes. Maintaining the bioenergetics of these cells is fundamental to maintaining the integrity of the intestine. In addition, L-glutamine helps maintain secretory IgA, which functions primarily by preventing the attachment of bacteria to mucosal cells.
Benefits of L-Glutamine:
Prevent Catabolization : Glutamine has been linked to protein synthesis. It prevents your muscle from being catabolized (eaten up) in order to provide Glutamine for other cells in the body.
Stay Hydrated : Glutamine helps maintain cell volume and hydration, speeding up wound healing and recovery.
Stay Charged: Glutamine helps replenish declining glutamine levels during intense episodes of immune disorders or diseases.
Increase Growth Hormones: L-Glutamine has show to spike hormone levels. Research has shown 2 grams of L-Glutamine increased growth by over 400%
Scientifically speaking, glutamine is one of the 20 amino acids formed by the human body. Glutamine is considered a non-essential amino acid because it can be derived from glutamic acid, another member of the amino acid family. Both glutamine and glutamic acid can be found in protein-rich foods such as beans, red meat, nuts and fish. The body uses glutamine to improve mental function, control blood sugar levels and maintain muscle mass, among other applications.
As a supplement, glutamine is seen as both a 'brain food' and a muscle mass enhancer for body builders. Physicians have been known to use glutamine for the treatment of alcoholism, mild depression and muscle-wasting conditions such as Huntington's disease. Glutamine is actually the most common free-form amino acid found floating in muscle tissues. During times of stress, the body may draw glutamine away from the muscles in order to bolster the immune system or prevent blood sugar reactions. This is why many bodybuilders and other proponents of supplements often add daily doses of glutamine to maintain good muscle health.
The average diet provides anywhere from 5 to 8 grams of glutamine a day. It would not be unusual for bodybuilders in training to boost this level to 10 grams or more with glutamine supplements. Others who need to control blood sugar levels may also benefit from additional glutamine. Some non-scientific studies suggest that glutamine may also help improve mental function, because the body naturally uses glutamine to transport nitrogen to the brain and nervous system.
The human body does require a daily intake of glutamine, so the use of supplements is not generally seen as harmful or unnecessary. Higher doses of glutamine may cause unpleasant side effects such as diarrhea, but most healthy bodies can safely assimilate the excess amino acid. Supplemental glutamine simply remains suspended in muscle tissue unless drawn away for other uses by the body. Some people also discover that elevated glutamine levels reduce their desire for sweets or between-meal snacks.
Now Remember the difference between glutamine peptides and regular L-glutamine Peptides are different from free form amino acids because they are basically 2 or more amino acids (building blocks of proteins) which are chemically linked to each other. Your body naturally takes whole proteins (made of long chains of aminos) and breaks them down through a natural hydrolyzation process to produce smaller and smaller peptides so they can be absorbed. Free form aminos like regular L-glutamine are just the single amino acid.
The glutamine dipeptides are typically L-glutamine bonded with either L-Alanine or L-Glycine. So you can look at this two ways as either a positive or a negative.
1. Peptides have a faster absorption rate in peptide form. Or
2. You are buying X number of grams of glutamine and in reality only getting 50% of that as actual glutamine.
Facts:
The maximum size amino chain your body can absorb is a 3 am ino peptide.
Nearly 75% of ingested protein is absorbed across the intestine in the form of peptides.
Why?
It is more efficient or “faster” for your body to absorb 3 am inos at a time vs. just one at a time. This is why companies say they are up to 150% more efficient than free form. Get it?
A problem with Peptides in my opinion:
Since amino acid peptides are more absorbed more quickly they may produce a greater insulin reaction. Depending on the timing this can be good or bad. Post workout is OK. However, most of the rest of the time you want to stabilize insulin reactions to avoid potential blood sugar fluctuations and subsequent possible body fat accumulation.
Research:
Other than speed of absorption, studies have shown that glutamine and glutamine dipeptides exert similar positive metabolic effects.
In one recent, double-blind, randomized, controlled study, duration of hospital stay was significantly reduced in patients who had undergone major abdominal surgery and who had received glutamine dipeptides via TPN over a five-day period. Mean cumulative nitrogen balance was significantly better in these patients, as was immune function.
The anticatabolic/anabolic action of both glutamine and glutamine dipeptides can be explained by their effect in sparing skeletal muscle L-glutamine stores. Most of the L-glutamine in the body is synthesized in skeletal muscle, where it is also stored. Under conditions of metabolic stress, skeletal muscle can be depleted of its L-glutamine, which is used for metabolic activities of other tissue/cells, such as enterocytes and lymphocytes (feeding the immune system to protect your main antioxidant glutathione).
The gastrointestinal mucosal-protective effect of the glutamine dipeptides can be explained in a few ways. L-glutamine is the preferred respiratory fuel for enterocytes and colonocytes. Maintaining the bioenergetics of these cells is fundamental to maintaining the integrity of the intestine. In addition, L-glutamine helps maintain secretory IgA, which functions primarily by preventing the attachment of bacteria to mucosal cells.
Benefits of L-Glutamine:
Prevent Catabolization : Glutamine has been linked to protein synthesis. It prevents your muscle from being catabolized (eaten up) in order to provide Glutamine for other cells in the body.
Stay Hydrated : Glutamine helps maintain cell volume and hydration, speeding up wound healing and recovery.
Stay Charged: Glutamine helps replenish declining glutamine levels during intense episodes of immune disorders or diseases.
Increase Growth Hormones: L-Glutamine has show to spike hormone levels. Research has shown 2 grams of L-Glutamine increased growth by over 400%
Last edited:
