Transdermals
I'm gonna try and make my own transdermal DHEA/Formestane combination.
I may experiment with other ingredients later on if I feel confident in doing this.
Got my scale which reads to .00 (hundredths of a gram) with 2 calibration weights 100 gram and 50 gram. Got my p0wders and am mostly set.
I have read that the p0wders to be used are best when molecular weights are less than 500 Daltons, preferably 300 or less (credit to Primordial Performance's website for that info).
DHEA molecular weight is 288.429
Formestane molecular weight is 302.4126
What I am curious about is the carrier agents. As many of you know, DMSO is well known for getting any agent thru the skin and into the bloodstream pretty well and fairly quickly. Other transdermals use various alcohols and other ingredients to slowly utilize the enzymes in the skin to convert over an extended period, like around 12 hours for something like Penetrate from Nutraplanet or Primordial Performance's topical solution. http://www.primordialperformance.com/topical_solution.cfm
My question is to anyone familiar with various compounds and carrier agents. Would DMSO be better to get a particular ingredient directly into the bloodstream (like formestane or any other AI) and would this shorten the half-life / effect of the compound? Or would it be better to put it in with the DHEA and use it over longer term in an alcohol based carrier? Would this compound get a longer half life if done this way?
First time around doing this, starting with easier/legal compounds.
I'm gonna try and make my own transdermal DHEA/Formestane combination.
I may experiment with other ingredients later on if I feel confident in doing this.
Got my scale which reads to .00 (hundredths of a gram) with 2 calibration weights 100 gram and 50 gram. Got my p0wders and am mostly set.
I have read that the p0wders to be used are best when molecular weights are less than 500 Daltons, preferably 300 or less (credit to Primordial Performance's website for that info).
DHEA molecular weight is 288.429
Formestane molecular weight is 302.4126
What I am curious about is the carrier agents. As many of you know, DMSO is well known for getting any agent thru the skin and into the bloodstream pretty well and fairly quickly. Other transdermals use various alcohols and other ingredients to slowly utilize the enzymes in the skin to convert over an extended period, like around 12 hours for something like Penetrate from Nutraplanet or Primordial Performance's topical solution. http://www.primordialperformance.com/topical_solution.cfm
My question is to anyone familiar with various compounds and carrier agents. Would DMSO be better to get a particular ingredient directly into the bloodstream (like formestane or any other AI) and would this shorten the half-life / effect of the compound? Or would it be better to put it in with the DHEA and use it over longer term in an alcohol based carrier? Would this compound get a longer half life if done this way?
First time around doing this, starting with easier/legal compounds.
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