Subcutaneous Test-E Injections Study

Strateg0s

Strateg0s

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Subcutaneous Test-E Injections Study

This is pretty interesting. The going advice is that sub-q injections have a lot of potential for causing abcesses. I'll try to track down the full text, and think through whether this has any potential for our purposes.

For instance, if the steroid molecule can crystalize yet not cause pain because it is injected into fat, that opens the way for some very high concentration mixes, ones no one in their right mind would inject IM. So if you were using a 300+300mg/ml formulation of test-e + test-c, 3/4cc 2x/wk would be a very high dose (900mg).

The study uses test-E, with no special ingredient to make it kosher sub-q:
Theramed said:
DELATESTRYL (Testosterone Enanthate Injection, U.S.P.) is a sterile long - acting preparation of an esterified derivate of naturally occurring hormone, testosterone in an oily solution for intramuscular use. It is available in a potency of 200 mg per mL formulated in sesame oil with 0.5 chlorobutanol as preservative.
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STABLE TESTOSTERONE LEVELS ACHIEVED WITH SUBCUTANEOUS TESTOSTERONE INJECTIONS
M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada

Objectives: The preferred technique of androgen replacement has been intramuscular (IM) testosterone, but wide variations in testosterone levels are often seen. Subcutaneous (SC) testosterone injection is a novel approach; however, its physiological effects are unclear. We therefore investigated the sustainability of stable testosterone levels using SC therapy. Patients and methods: Between May and September 2005, we conducted a small pilot study involving 10 male patients with symptomatic late-onset hypogonadism.

Every patient had been stable on TE 200 mg IM for 1 year. Patients were instructed to self-inject with testosterone enanthate (TE) 100 mg SC (DELATESTRYL 200 mg/cc, Theramed Corp, Canada) into the anterior abdomen once weekly. Some patients were down-titrated to 50 mg based on their total testosterone (T) at 4 weeks.

Informed consent was obtained as SC testosterone administration is not officially approved by Health Canada. T levels were measured before and 24 hours after injection during weeks 1, 2, 3, and 4, and 96 hours after injection in week 6 and 8.

At week 12, PSA, CBC, and T levels were measured however; the week 12 data are still being collected.

Results: Prior to initiation of SC therapy, T was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit 0.47+0.02, and PSA 1.05+0.65 ng/ml. During the first 4 weeks, there was a steady increase in pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l (p¼0.1). However, after 8 weeks the post-injection T (25.77+7.67 nmol/l) remained similar to that of week 1 (27.46+12.91 nmol/l). Patients tolerated this therapy with no adverse effects.

Conclusions: A once-week SC injection of 50–100 mg of TE appears to achieve sustainable and stable levels of physiological T. This technique offers fewer physician visits and the use of smaller quantity of medication, thus lower costs. However, the long term clinical and physiological effects of this therapy need further evaluation.
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I can't find the full-text. Not knowing which journal it is from doesn't help. Can anyone track it down?

I did come across a post on the topic of sub-q injections, from eons ago, http://www.mindandmuscle.net/forum/index.php?showtopic=8130.
 
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