A Low-Carb Diet Can Hurt Your Memory,,

M FREAKY

Super Moderator
A Low-Carb Diet Can Hurt Your Memory,,

Low-carbohydrate diets are notoriously difficult to adhere to for long periods of time. Many of my patients have tried a low-carb diet and lost weight, some over 100 pounds, but most often the weight came back... and then some. Repeatedly gaining and losing weight (yo-yo dieting) can slow metabolism and pose risks to your overall health. Now, scientific studies are questioning whether these diets are dangerous to your brain's memory function, too.

Slower brain functions

Researchers at Tufts University have found that dieters who strive to eliminate most carbohydrates from their diets scored significantly lower on memory-based tasks than did subjects who simply reduced the amount of calories they ate.

The study subjects included 19 women ages 22 to 55, 9 of whom were put on a low-carbohydrate diet and 10 on a low-calorie but balanced diet. All subjects attended 5 memory-testing sessions in which their spatial memory, attention, cognitive skills, and short and long-term memory were assessed. These sessions were conducted throughout the 3 weeks of the study.

After 1 week of severe carbohydrate restriction, memory performance among the low-carb group, especially when dealing with difficult tasks, gradually decreased compared with the low-calorie group. In addition, the low-carb dieters had slower reaction times and faltered during tests of their visual-spatial memory.

Feeding the brain

The brain uses glucose as its main fuel but has no way of storing it for future use. The nerve cells use glucose immediately for energy, and if they cannot get this fuel, they aren't able to operate at peak capacity -- potentially leaving you feeling forgetful or unable to concentrate.

I read a study recently that found students and others who continually challenge their minds actually require more carbohydrates, and thus, seem to crave carbohydrate foods in direct proportion to how much they have to exert their brains. Perhaps carbohydrate cravings in such cases are the body's way of getting the brain the fuel it needs.

This study only tracked the dieters for 3 weeks and the study's sample size was small, but the authors suggest that, although low-carb diets can affect weight, they result in a lack of glucose to the brain that may be detrimental to learning, memory, and thinking.

According to the Tufts study, the popular low-carb diets—and particularly the "no-carb" diets—have the biggest potential for decreasing the ability to think and concentrate, and may also negatively affect overall mood. This could be one of the reasons many people have a hard time sticking with a no-carb meal plan.

What you need to know

Although carb-free diets may seem appealing, aim for at least a moderate amount of carbohydrate in your diet. In my weight-loss/nutrition practice at Johns Hopkins Bayview Medical Center, I refer to clinical research findings that suggest that for optimal function the human brain needs a minimum of 125 grams of carbohydrate each day.

To put this into perspective, 1 medium piece of fruit or a slice of bread is about 15 grams of carbohydrate. So if you aim for 6 servings of whole grains per day for a balanced diet, that's 90 grams right there. Similarly, 1 cup of cooked rice provides 3 servings of starch or 45 grams of carbohydrate, while an 8-ounce glass of milk will give you another 12 grams of carbs.

If you aimed for 3 starches, 3 fruits, 4 vegetables, and 1 (8-oz) glass of milk a day, you're right around the 125-gram goal, which should keep your brain clear and your body energized -- and will supply plenty of vitamins, minerals, and fiber for a healthy, balanced diet. To find healthy meal guidelines, go to the USDA's MyPyramid Web site, or see a registered dietitian who can provide you with an individualized meal plan.
It's a good idea to limit the carbs from processed foods, such as those little snack packs containing 100 calories. They may seem like a bargain but they're generally devoid of vitamins, minerals, and fiber and leave you feeling even hungrier an hour later.
If you're not sure if your brain is really hankering for carbs or you're just bored, wait about 30 minutes before you eat and see if you feel either true physical signs of hunger or signs of carb deprivation (e.g., irritability, feelings stemming from low blood sugar, and shakiness or dizziness).
 

vtliftvt

Trusted Member
I have found that yes, low carb diets greatly reduce cognitive function however periods of time with low carbs (such as cycling) increases insulin sensitivity and further enhances congitive function. I have been reading some research on alternate day fasting and it seems very useful for weight loss while still holding muscle and longevity as well.
 

Vicious Cycle

Trusted Member
I have found that yes, low carb diets greatly reduce cognitive function however periods of time with low carbs (such as cycling) increases insulin sensitivity and further enhances congitive function. I have been reading some research on alternate day fasting and it seems very useful for weight loss while still holding muscle and longevity as well.
Interesting - post more please.
 

vtliftvt

Trusted Member
Few Studies

I am not sure if any of you are familiar with DatBTrue's research but here are a few snippets related to the topic: NOTE, I TAKE NO CREDIT FOR ANY OF THIS NOR AM I TRYING TO ACT LIKE IT. JUST THINK THIS IS EXTREMELY INTERESTING STUFF.

I became very interested in every other day calorie restriction when I experimented for years with it on myself and found that if I alternated between:

a day of very low calories (say between 1000 & 1400) w/ food intake primarily at the beginning and end of the day & cardio exercise(s) in the earlier portion of the day followed by no food intake for several hours...

and a day where I ate at about maintenence w/ a higher intake of carbs around a session of weightlifing.

I could readily lose fat & retain muscle. In fact I always made minor but consistent strength gains and felt mentally sharp & had energy during the fasted portion of low cal day.

I have been researching a pattern of eating involving a day of eating less then 20% of maintenance calories (or a complete fast) followed by eating freely (but not excessively). I have very little doubt that this pattern is as beneficial as calorie restriction diets in promoting longevity. But has the advantage of preserving body mass.

It is interesting that on fasted days there is no depletion of glycogen from muscle, circulating levels do go down but stores are drawn from the liver. I conjecture that during periods of no energy intake the body preserves muscle as best it can (at least in the 24 hour period) so that the homo sapien can use his strength to obtain more energy. *

What is interesting is that the following non-fasted day when energy intake is occurring the body is more insulin sensitive. In fact over time w/ this pattern of eating the body can become up to 7 times more insulin sensitive.

The area that I am attempting to reconcile is whether the use of GHRH/GHRP-6 to restore youthful GH levels (and a little higher IGF-1 levels) undermines the longevity benefits of alternate day calorie restriction?

Resveratrol I suspect is not the answer to longevity in humans even though it mimics many of the transcriptional aspects of calorie restriction. It has been shown not to extend lifespan in normal mice. **

Eating at 60% of maintenance every day is not desirable, but EOD calorie restriction might be the answer to health and longevity while maintaining the body in a fit muscular state.

* - "With the present fasting protocol and maintenance of habitual daily physical activity in the fasting periods, we had expected to detect a decrease in IMTG content in the skeletal muscle. The fact that this was not seen and that muscle glycogen content was unchanged could suggest that skeletal muscle is not immediately involved in recognition of acute energy oscillations." - Effect of intermittent fasting and refeeding on insulin action in healthy men, Nils Halberg, J Appl Physiol 99: 2128-2136, 2005

** - Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span, Pearson KJ , Cell Metab. 2008 Aug;8(2):157-68.
 
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vtliftvt

Trusted Member
STUDY: Effect of intermittent fasting and refeeding on insulin action in healthy men

Another:

Eight healthy young Caucasian men, body mass index 25.7 +- 0.4 kg/m2

Throughout the intervention, the subjects were instructed to uphold their normal exercise habits, to maintain their usual macronutrient mixing of their meals, and to eat sufficient quantities of food on the nonfasting days to ensure that their body weight was stable.

The fast period was 20 hours. Each fasting period started at 2200 and ended at 1800 the following day (for protocol see Fig. 1). During the fasting periods the subjects were allowed to drink water and were instructed to maintain habitual activities.




CONCLUSION:

In conclusion, the findings that intermittent fasting increases insulin sensitivity on the whole body level as well as in adipose tissue support the view that cycles of feast and famine are important as an initiator of thrifty genes leading to improvements in metabolic function (6). We suggest that a fastinginduced increase in circulating adiponectin is at least partly responsible for this finding. The change in adiponectin, together with changes in plasma leptin with fasting, underlines the important role of the adipose tissue in recognizing the oscillation in energy stores. Finally, the data indicate that intermittent fasting and physical training may increase insulin action via different mechanisms because muscle energy stores did not change with the present fasting intervention.
Eight healthy young Caucasian men, body mass index 25.7 +- 0.4 kg/m2

Throughout the intervention, the subjects were instructed to uphold their normal exercise habits, to maintain their usual macronutrient mixing of their meals, and to eat sufficient quantities of food on the nonfasting days to ensure that their body weight was stable.

The fast period was 20 hours. Each fasting period started at 2200 and ended at 1800 the following day (for protocol see Fig. 1). During the fasting periods the subjects were allowed to drink water and were instructed to maintain habitual activities.
 

vtliftvt

Trusted Member
Alt. Day Fasting = increase lifespan

The authors of the study, The effect on health of alternate day calorie restriction: Eating less and more than needed on alternate days prolongs life, James B. Johnson, Medical Hypotheses (2006) 67, 209–211 made the following claim and hypothesis before reexamining a study that took place in Spain the 1950's which supports their claim.

"Restricting caloric intake to 60–70% of normal adult weight maintenance requirement prolongs lifespan 30–50% and confers near perfect health across a broad range of species. Every other day feeding produces similar effects in rodents, and profound beneficial physiologic changes have been demonstrated in the absence of weight loss in ob/ob mice. Since May 2003 we have experimented with alternate day calorie restriction, one day consuming 20– 50% of estimated daily caloric requirement and the next day ad lib eating, and have observed health benefits starting in as little as two weeks, in insulin resistance, asthma, seasonal allergies, infectious diseases of viral, bacterial and fungal origin (viral URI, recurrent bacterial tonsillitis, chronic sinusitis, periodontal disease), autoimmune disorder (rheumatoid arthritis), osteoarthritis, symptoms due to CNS inflammatory lesions (Tourette’s, Meniere’s) cardiac arrhythmias (PVCs, atrial fibrillation), menopause related hot flashes. We hypothesize that other many conditions would be delayed, prevented or improved, including Alzheimer’s, Parkinson’s, multiple sclerosis, brain injury due to thrombotic stroke atherosclerosis, NIDDM, congestive heart failure."
I have been on an every other day diet for a couple of months now w/ one of those days below 50% of my maintenance and I feel pretty darn good. The most noticeable effect is a sharper mind/memory although part of that effect comes from my EOD intake of Mucuna pruriens, 40% L-Dopa w/ GHRPs. - **

** - Ghrelin Amplifies Dopamine Signaling by Cross Talk Involving Formation of Growth Hormone Secretagogue Receptor/Dopamine Receptor Subtype 1 Heterodimers, Hong Jiang, Lorena Betancourt, and Roy G. Smith, Molecular Endocrinology 2006 20(8):1772–1785

"In summary, our results demonstrate that GHS-R and D1R are coexpressed in the same neurons and that ghrelin has the capacity to amplify dopamine signaling by a mechanism associated with GHS-R/D1R heterodimer formation. Because ghrelin production is cyclical, this pathway provides temporal control over the magnitude of dopamine signaling in neurons expressing both receptors. A decline in dopamine signaling occurs during aging that is not accompanied by reduced D1R expression in humans, but might be linked to the precipitous decline in expression of the dopamine transporter (44, 45). Therefore, amplifying D1R signaling in a neuronal specific way by administering ghrelin or a ghrelin mimetic could counteract age-related attenuation of dopamine function and benefit cognitive function in the elderly. Finally, our findings provide new information on the potentially broad neuromodulatory roles of ghrelin and GHS-R and invite speculation on their potential for a more profound role in modifying intracellular signaling of other neurotransmitter-activated GPCRs."
 
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